Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hec1 Analogues
- 25 February 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 52 (6), 1757-1767
- https://doi.org/10.1021/jm8015969
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivoProceedings of the National Academy of Sciences of the United States of America, 2008
- Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in AnimalCancer Research, 2008
- Hice1, a Novel Microtubule-Associated Protein Required for Maintenance of Spindle Integrity and Chromosomal Stability in Human CellsMolecular and Cellular Biology, 2008
- The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stabilityOncogene, 2008
- Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlOncogene, 2006
- Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2BBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
- Suppression ofNek2Ain mouse early embryos confirms its requirement for chromosome segregationJournal of Cell Science, 2004
- Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failureExperimental Cell Research, 2004
- Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome SegregationPublished by Elsevier BV ,2002
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002