Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer
Open Access
- 1 July 2001
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (13), 6199-6203
- https://doi.org/10.1128/jvi.75.13.6199-6203.2001
Abstract
Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated for muscle-directed gene transfer (called AAV2/5). Evaluation in immune-competent mice revealed greater transduction efficacy with AAV2/5 than with AAV2 and no cross-neutralization between AAV2/5 and AAV2. Interestingly, we saw no immunologic evidence of previous exposure to AAV5 capsids in a large population of healthy human subjects.Keywords
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