Unified Mechanistic Framework for the Fe(II)-Induced Cleavage of Qinghaosu and Derivatives/Analogues. The First Spin-Trapping Evidence for the Previously Postulated Secondary C-4 Radical
- 26 March 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 120 (14), 3316-3325
- https://doi.org/10.1021/ja973080o
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activityTetrahedron Letters, 1997
- Characterization of the First Covalent Adduct between Artemisinin and a Heme ModelJournal of the American Chemical Society, 1997
- Oxidative Damage to DNA Constituents by Iron-mediated Fenton ReactionsJournal of Biological Chemistry, 1996
- Evidence for the Importance of High-Valent FeO and of a Diketone in the Molecular Mechanism of Action of Antimalarial Trioxane Analogs of ArtemisininJournal of the American Chemical Society, 1996
- Iron(II)-mediated rearrangement of 1,2,4-trioxanes into 1,2-diol monoesters via 1,5-hydrogen transferTetrahedron Letters, 1995
- Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial ArtemisininJournal of the American Chemical Society, 1995
- Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu).Journal of the American Chemical Society, 1992
- DNA Damage and Oxygen Radical ToxicityScience, 1988
- The design of resolving agents. Chiral cyclic phosphoric acidsThe Journal of Organic Chemistry, 1985
- Studies on the Constituents of Artemisia annua Part II*Planta Medica, 1982