Association of Human Bocavirus 1 Infection with Respiratory Disease in Childhood Follow-up Study, Finland
Open Access
- 1 February 2012
- journal article
- research article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 18 (2), 264-271
- https://doi.org/10.3201/eid1802.111293
Abstract
Human bocavirus 1 (HBoV1) DNA is frequently detected in the upper airways of young children with respiratory symptoms. Because of its persistence and frequent co-detection with other viruses, however, its etiologic role has remained controversial. During 2009–2011, using HBoV1 IgM, IgG, and IgG-avidity enzyme immunoassays and quantitative PCR, we examined 1,952 serum samples collected consecutively at 3- to 6-month intervals from 109 constitutionally healthy children from infancy to early adolescence. Primary HBoV1 infection, as indicated by seroconversion, appeared in 102 (94%) of 109 children at a mean age of 2.3 years; the remaining 7 children were IgG antibody positive from birth. Subsequent secondary infections or IgG antibody increases were evident in 38 children and IgG reversions in 10. Comparison of the seroconversion interval with the next sampling interval for clinical events indicated that HBoV1 primary infection, but not secondary immune response, was significantly associated with acute otitis media and respiratory illness.Keywords
This publication has 35 references indexed in Scilit:
- Human Bocaviruses Are Highly Diverse, Dispersed, Recombination Prone, and Prevalent in Enteric InfectionsThe Journal of Infectious Diseases, 2010
- Human Bocavirus in ChildrenThe Pediatric Infectious Disease Journal, 2010
- PROLONGED DETECTION OF HUMAN BOCAVIRUS DNA IN NASOPHARYNGEAL ASPIRATES OF CHILDREN WITH RESPIRATORY TRACT DISEASEThe Pediatric Infectious Disease Journal, 2009
- A Novel Bocavirus Associated with Acute Gastroenteritis in Australian ChildrenPLoS Pathogens, 2009
- A Newly Identified Bocavirus Species in Human StoolThe Journal of Infectious Diseases, 2009
- Human Bocavirus Infection in Children With Respiratory Tract DiseaseThe Pediatric Infectious Disease Journal, 2008
- Clinical and Epidemiologic Characteristics of Human Bocavirus in Danish InfantsThe Pediatric Infectious Disease Journal, 2008
- Human Bocavirus: Passenger or Pathogen in Acute Respiratory Tract Infections?Clinical Microbiology Reviews, 2008
- Human Bocavirus Infections in Hospitalized Children and AdultsEmerging Infectious Diseases, 2008
- Cloning of a human parvovirus by molecular screening of respiratory tract samplesProceedings of the National Academy of Sciences of the United States of America, 2005