Predicting Odor Pleasantness from Odorant Structure: Pleasantness as a Reflection of the Physical World
Open Access
- 12 September 2007
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (37), 10015-10023
- https://doi.org/10.1523/jneurosci.1158-07.2007
Abstract
Although it is agreed that physicochemical features of molecules determine their perceived odor, the rules governing this relationship remain unknown. A significant obstacle to such understanding is the high dimensionality of features describing both percepts and molecules. We applied a statistical method to reduce dimensionality in both odor percepts and physicochemical descriptors for a large set of molecules. We found that the primary axis of perception was odor pleasantness, and critically, that the primary axis of physicochemical properties reflected the primary axis of olfactory perception. This allowed us to predict the pleasantness of novel molecules by their physicochemical properties alone. Olfactory perception is strongly shaped by experience and learning. However, our findings suggest that olfactory pleasantness is also partially innate, corresponding to a natural axis of maximal discriminability among biologically relevant molecules.Keywords
This publication has 58 references indexed in Scilit:
- Methods for building an olfactometer with known concentration outcomesJournal of Neuroscience Methods, 2007
- Broad activation of the olfactory bulb produces long-lasting changes in odor perceptionProceedings of the National Academy of Sciences of the United States of America, 2006
- Speed-Accuracy Tradeoff in OlfactionNeuron, 2006
- Attentional modulation in human primary olfactory cortexNature Neuroscience, 2004
- The Effects of Hedonic Properties of Odors and Attentional Modulation on the Olfactory Event-Related Potentials.Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science, 2001
- From molecule to mind: the role of experience in shaping olfactory functionJournal of Comparative Physiology A, 1999
- Chemistry of odor stimuliCellular and Molecular Life Sciences, 1986
- Lability of Odor Pleasantness: Influence of Mere ExposurePerception, 1978
- An approach to a physico-chemical model of olfactory stimulation in vertebrates by single compoundsJournal of Theoretical Biology, 1973
- Odor pleasantness and intensity: A single dimension?Journal of Experimental Psychology, 1971