Effect of IgG anti‐Rho(D) in adult patients with chronic autoimmune thrombocytopenia
- 11 July 1986
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 22 (3), 241-250
- https://doi.org/10.1002/ajh.2830220304
Abstract
Seventeen adult patients with chronic (15 cases) or acute (two cases) autoimmune thrombocytopenia (ITP) were given intravenous and/or intramuscular injections of 0.75–4.5 mg of IgG anti‐Rho(D) over a period of 1–5 days. Significant elevations of the platelet count (increments > 50 × 109/liter) resulted in 13 of 15 Rh‐positive patients but not in either of two Rh‐negative patients. Heat‐aggregated human albumin given to one of the Rh‐negative patients also did not lead to a significant increase of the platelet count. The elevation of the platelet counts in Rh‐positive patients after IgG anti‐Rho(D) administration was often transient (< 4 weeks), but long‐term benefit (> 5 months) was achieved in five cases. The IgG concentration on RBC from five Rh‐positive patients studied increased from a usually undetectable value before to ∼ 700–1,700 IgG molecules/per RBC after anti‐RhoD) administration resulting in a strongly positive direct antiglobulin test. Nevertheless, an overt clinical hemolysis was seen in only one patient. The clearance of autologous 51Cr‐labeled RBC was determined in four patients and was slightly enhanced in three and normal in one splenectomized patient. We conclude that the Fc receptor blockade involved in platelet sequestration was not associated with the induction of significant RBC clearance and that a reversible interaction of sensitized RBC with phagocytic cells and/or a low‐grade destruction of these cells might be sufficient for the elevation of circulating platelets in the majority of patients with ITP.Keywords
This publication has 18 references indexed in Scilit:
- Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies (anti-Rh0(D))Blut: Zeitschrift für die Gesamte Blutforschung, 1984
- EFFECT OF INTRAVENOUS IMMUNOGLOBULIN IN IMMUNE THROMBOCYTOPENIA: Competitive Inhibition of Reticuloendothelial System Function by Sequestration of Autologous Red Blood Cells?The Lancet, 1983
- Platelet associated IgG, platelet survival, and platelet sequestration in thrombocytopenic statesBritish Journal of Haematology, 1982
- The Clinical Significance of Platelet‐Associated IgG: a Study on 298 Patients with Various DisordersBritish Journal of Haematology, 1980
- Recommended Method for Radioisotope Red‐Cell Survival Studies. International Committee for Standardization in Haematology*British Journal of Haematology, 1980
- THE EFFECT OF ISOANTIBODIES ON RED-CELL SURVIVALAnnals of the New York Academy of Sciences, 1970
- QUANTITATIVE STUDIES OF THE EFFECT OF RED-BLOOD-CELL SENSITIZATION ON IN VIVO HEMOLYSIS*JCI Insight, 1963
- STUDIES OF THE RETICULOENDOTHELIAL SYSTEM (RES). I. MEASUREMENT OF THE PHAGOCYTIC CAPACITY OF THE RES IN MAN AND DOG*JCI Insight, 1963
- Efficient Trace-labelling of Proteins with IodineNature, 1958
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949