Acetylcholine receptor channel imaged in the open state
- 1 January 1995
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 373 (6509), 37-43
- https://doi.org/10.1038/373037a0
Abstract
The structure of the open-channel form of the acetylcholine receptor has been determined from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5 ms) mixing with droplets containing acetylcholine. Comparison with the closed-channel form shows that acetylcholine initiates small rotations of the subunits in the extracellular domain, which trigger a change in configuration of alpha-helices lining the membrane-spanning pore. The open pore tapers towards the intracellular membrane face, where it is shaped by a 'barrel' of alpha-helices having a pronounced right-handed twist.Keywords
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