Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia
Open Access
- 20 May 2009
- journal article
- Published by Springer Science and Business Media LLC in BMC Medical Genomics
- Vol. 2 (1), 28
- https://doi.org/10.1186/1755-8794-2-28
Abstract
Many critical maturational processes take place in the human brain during postnatal development. In particular, the prefrontal cortex does not reach maturation until late adolescence and this stage is associated with substantial white matter volume increases. Patients with schizophrenia and other major psychiatric disorders tend to first present with overt symptoms during late adolescence/early adulthood and it has been proposed that this developmental stage represents a "window of vulnerability".Keywords
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