New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation
Open Access
- 4 November 2013
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 14 (11), 21805-21818
- https://doi.org/10.3390/ijms141121805
Abstract
New pyrazole derivatives were designed and synthesized as potential protein kinase inhibitors in the view to develop specific antitumor therapies. The structures of the compounds were elucidated using spectral and elemental analyses. The antitumor potential was estimated using wheat seeds and the general toxicity was evaluated by alternative methods, using invertebrate animals. One 3-aminopyrazole derivative emerged as a potential candidate for the development of future cytotoxic compounds.Keywords
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