Skin irritation caused by transdermal drug delivery systems during long-term (5 days) application
- 1 April 1985
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 112 (4), 461-467
- https://doi.org/10.1111/j.1365-2133.1985.tb02321.x
Abstract
We have studied the skin irritation produced by the prolonged application of transdermal therapeutic systems. The systems were applied to the skin of the back of male volunteers for 120 hours, and sweat accumulation and bacterial growth were studied. In some cases hydrogel discs were attached to the systems. The results showed that sweat accumulation contributed more to the skin irritation than the bacterial overgrowth. The incorporation of hydrogels in the transdermal delivery system may help to reduce skin irritation by absorbing water.Keywords
This publication has 6 references indexed in Scilit:
- ALLERGIC CONTACT DERMATITIS WITH TRANSDERMAL CLONIDINEThe Lancet, 1983
- Effect of Prolonged Occlusion on the Microbial Flora, pH, Carbon Dioxide and Transepidermal Water Loss on Human SkinJournal of Investigative Dermatology, 1978
- Growth of bacteria under adhesive tapesArchives of Dermatology, 1969
- Cutaneous Hypersensitivity to Adhesive and Scotch® Tapes11From the Lovelace Foundation for Medical Education and Research, and the Lovelace Clinic, Albuquerque, New Mexico.Journal of Investigative Dermatology, 1958
- FURTHER STUDIES ON THE MECHANISM OF ADHESIVE TAPE DERMATITISArchives of Dermatology, 1951
- The Mechanism of Adhesive Plaster Irritation11From the Dermatologic Service and Laboratories of the Mount Sinai Hospital, New York City.Journal of Investigative Dermatology, 1948