Systemic methotrexate for the treatment of psoriasis
- 16 March 2015
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Clinical Immunology
- Vol. 11 (5), 553-563
- https://doi.org/10.1586/1744666x.2015.1026894
Abstract
In the era of biologic therapies, methotrexate (MTX), a classic immunomodulator, is still the cornerstone of systemic treatment of psoriasis. MTX has been used for many years, achieving good responses with a good safety profile. However, only a few randomized clinical trials have been performed involving MTX, and most of the current evidence comes from pivotal studies of biologic drugs. The aim of this article is to make an extensive review of the MTX mechanism of action, pharmacokinetics, efficacy, safety and tolerability, especially focusing on the future perspective of this old drug and recent advances in the field of pharmacogenetics.Keywords
This publication has 81 references indexed in Scilit:
- Rationale and Design of the TETHYS Trial: The Effects of Methotrexate Therapy on Myocardial Infarction with ST-Segment ElevationJMIR AI, 2013
- A randomized, double‐blind, placebo‐controlled study to evaluate the addition of methotrexate to etanercept in patients with moderate to severe plaque psoriasisBritish Journal of Dermatology, 2012
- Systematic Review and Meta-Analysis of Methotrexate Use and Risk of Cardiovascular DiseaseThe American Journal of Cardiology, 2011
- The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a reviewArthritis Research & Therapy, 2010
- EADV preceptorship: advances in dermatologyJournal of the European Academy of Dermatology and Venereology, 2010
- PsoriasisNew England Journal of Medicine, 2009
- Methotrexate catabolism to 7‐hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementationArthritis & Rheumatism, 2009
- Methotrexate: Understanding the risk in psoriasis patientsJournal of Dermatological Treatment, 2009
- Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA studyArthritis Research & Therapy, 2008
- Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's diseaseGut, 2007