Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases
- 1 March 1987
- journal article
- case report
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 74 (3), 198-201
- https://doi.org/10.1002/bjs.1800740315
Abstract
Five patients with the Zollinger—Ellison syndrome who had extra-pancreatic (duodenal or paraduodenal) gastrinoma with lymph node metastases responded favourably to simple excision or mere shelling out of macroscopic tumour. Acid studies, serum gastrin and the secretin test became normal in all cases in the immediate postoperative period and remained so in three of the five patients when tested at 57, 33 and 8 months. The tests became abnormal in two patients when tested 8 and 53 months after surgery, but both patients are currently well-controlled on ranitidine 150 mg b.d. 22 and 65 months respectively after surgery. These results suggest that in patients with extra-pancreatic gastrinoma who have lymph node metastases simple excision of all macroscopic tumours may offer the prospect of long-term control. The place of total gastrectomy in such patients is questioned.Keywords
This publication has 16 references indexed in Scilit:
- Vagotomy in the management of patients with Zollinger-Ellison syndrome: Pros and consGastroenterology, 1985
- Treatment of Zollinger-Ellison syndrome with exploratory laparotomy, proximal gastric vagotomy, and H2-receptor antagonistsGastroenterology, 1985
- Benign and malignant gastrinomaThe American Journal of Surgery, 1985
- Removal of Gastrinomas for Control of Zollinger-Ellison SyndromeAnnals of Surgery, 1984
- Conservative surgey in the Zollinger–Ellison syndromeBritish Journal of Surgery, 1984
- The gastrinoma triangle: Operative implicationsThe American Journal of Surgery, 1984
- Extrapancreatic, Extraintestinal GastrinomaNew England Journal of Medicine, 1982
- Treatment of the Zollinger-Ellison syndrome: A 25 year assessmentThe American Journal of Surgery, 1982
- The Place of Surgery in the Zollinger-Ellison SyndromeNew England Journal of Medicine, 1980
- The effect of vagotomy on human gastric secretionBritish Journal of Surgery, 1970