Clinical and biochemical manifestations of syndrome X in obese children
- 6 July 2004
- journal article
- Published by Springer Science and Business Media LLC in European Journal of Pediatrics
- Vol. 163 (10), 573-579
- https://doi.org/10.1007/s00431-004-1483-0
Abstract
The aim of this study was to investigate whether the clinical and metabolic characteristics of syndrome X had their onset in childhood in otherwise healthy but obese children of Greek origin. A group of 25 obese children and 18 age- and sex matched control subjects, aged 6–14 years, underwent an oral glucose tolerance test (OGTT), assessed for determination of plasma glucose and insulin levels. Insulin sensitivity and insulin resistance were estimated by mathematical models using calculations obtained during the OGTT. Body mass index (BMI) and blood pressure were measured, as well as serum lipoprotein and aminotransferase concentrations, after an overnight fast. The obese children had significantly higher blood pressure (systolic and diastolic) (PPPPPP Conclusion:childhood adiposity was associated with all traditional components of syndrome X. The early recognition of these factors as predisposing elements of the appearance of metabolic syndrome requires the development of strategies to manage excess weight gain during childhood, with the ultimate goal being the prevention of type 2 diabetes and cardiovascular disease in adulthood.Keywords
This publication has 29 references indexed in Scilit:
- Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver diseaseThe Journal of Pediatrics, 2003
- Evaluation of the Insulin Resistance Syndrome in 5- to 10-Year-Old Overweight/Obese African-American ChildrenDiabetes Care, 2001
- Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.Diabetes Care, 2000
- Overweight Children and Adolescents: Description, Epidemiology, and DemographicsPediatrics, 1998
- Relation of Fasting Insulin to Blood Pressure and Lipids in Adolescents and ParentsHypertension, 1997
- Update: prevalence of overweight among children, adolescents, and adults--United States, 1988-1994.1997
- Insulin sensitivity, lipids, and body composition in childhood: is "syndrome X" present?Journal of Clinical Endocrinology & Metabolism, 1996
- Association of Fasting Insulin Level With Serum Lipid and Lipoprotein Levels in Children, Adolescents, and Young Adults: The Bogalusa Heart StudyArchives of Internal Medicine, 1995
- Effects of doxazosin, a selective α1-inhibitor, on plasma insulin and blood glucose response to a glucose tolerance test in essential hypertensionMetabolism, 1993
- Molecular Physiology and Genetics of NIDDM: Importance of Metabolic StagingDiabetes Care, 1992