Renal cell cancer stage migration
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Open Access
- 20 June 2008
- Vol. 113 (1), 78-83
- https://doi.org/10.1002/cncr.23518
Abstract
BACKGROUND. Evidence exists to suggest a pattern of increasing early diagnosis of renal cell carcinoma (RCC). The aim of the study was to analyze patterns of disease presentation and outcome of RCC by AJCC stage using data from the National Cancer Data Base (NCDB) over a 12-year period. METHODS. The NCDB was queried for adults diagnosed between 1993 and 2004 presenting with ICD-O-2 of 3 renal cell tumors arising in the kidney. Cases were classified by demographics, 2002 AJCC stage (6th edition), and histology. The Cochran-Armitage Test for Trend was used to determine statistical significance of trends over time. Cox regression multivariate analysis was used to evaluate the impact of stage and histology on relative survival. SPSS 14.0 was used for analyses. RESULTS. Between 1993 and 2004 a total of 205,963 patients from the NCDB fit our case definition of RCC. Comparisons between 1993 and 2004 data show an increase in stage I disease and decrease in stage II, III, and IV disease (P ≤ .001). The size of stage I tumors also decreased from a mean of 4.1 cm in 1993 to 3.6 cm in 2003. In multivariate analysis, stage, but not histology, predicted relative survival. A 3.3% increase in survival was found for patients diagnosed in 1998 compared with patients diagnosed in 1993. CONCLUSIONS. A greater proportion of newly diagnosed patients with RCC currently present with stage I disease compared with earlier years. Stage predicts relative survival for patients with kidney cancer. More recently diagnosed patients have improved relative survival. Cancer 2008. © 2008 American Cancer Society.Keywords
This publication has 20 references indexed in Scilit:
- Rising Incidence of Small Renal Masses: A Need to Reassess Treatment EffectJNCI Journal of the National Cancer Institute, 2006
- Cancer Statistics, 2006CA: A Cancer Journal for Clinicians, 2006
- Utilization of Radiology Services in the United States: Levels and Trends in Modalities, Regions, and PopulationsRadiology, 2005
- Renal Cell Carcinoma Detected by Screening Shows Better Patient Survival Than That Detected Following Symptoms in Dialysis PatientsTherapeutic Apheresis and Dialysis, 2004
- Global increases in kidney cancer incidence, 1973–1992European Journal of Cancer Prevention, 2002
- AJCC Cancer Staging ManualPublished by Springer Science and Business Media LLC ,2002
- INCREASING INCIDENCE OF ALL STAGES OF KIDNEY CANCER IN THE LAST 2 DECADES IN THE UNITED STATES: AN ANALYSIS OF SURVEILLANCE, EPIDEMIOLOGY AND END RESULTS PROGRAM DATAJournal of Urology, 2002
- Localized renal cell carcinomaCurrent Treatment Options in Oncology, 2001
- Rising Incidence of Renal Cell Cancer in the United StatesJAMA, 1999
- Regional diversity and breadth of the National Cancer Data BaseCancer, 1998