Intravesical Mitomycin C Therapy for Superficial Bladder Cancer. Report of a Multicentre Phase II Study

Abstract
Patients (25) with early transitional cell carcinoma of the bladder (Tis Ta T1) received intravesical instillations of 40 mg mitomycin C in 40 ml water weekly for 7 wk. The overall response rate was 70% (complete response 40%). In patients with Ta tumors the response rate was 86%. Minor toxic side effects occurred in 4 patients and only 1 patient was unable to complete the course of treatment because of side effects.