A Novel Two-Step Hierarchical Quantitative Structure–Activity Relationship Modeling Work Flow for Predicting Acute Toxicity of Chemicals in Rodents
- 1 August 2009
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 117 (8), 1257-1264
- https://doi.org/10.1289/ehp.0800471
Abstract
A peer-reviewed open access journal published by the National Institute of Environmental Health SciencesKeywords
This publication has 34 references indexed in Scilit:
- Computational Molecular Modeling for Evaluating the Toxicity of Environmental Chemicals: Prioritizing Bioassay RequirementsEnvironmental Health Perspectives, 2008
- Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative Structure–Activity Relationship Models of Animal CarcinogenicityEnvironmental Health Perspectives, 2008
- Compound Cytotoxicity Profiling Using Quantitative High-Throughput ScreeningEnvironmental Health Perspectives, 2008
- Transforming Environmental Health ProtectionScience, 2008
- Quantitative structure−pharmacokinetic parameters relationships (QSPKR) analysis of antimicrobial agents in humans using simulated annealing k‐nearest‐neighbor and partial least‐square analysis methods**This paper was presented in part at the Annual Meeting of the American Association of Pharmaceutical Scientists in Toronto in 2003.Journal of Pharmaceutical Sciences, 2004
- Assessment of the Oral Rat Chronic Lowest Observed Adverse Effect Level Model in TOPKAT, a QSAR Software Package for Toxicity PredictionJournal of Chemical Information and Computer Sciences, 2004
- Multiple computer-automated structure evaluation study of aquatic toxicity II. Fathead minnowEnvironmental Toxicology and Chemistry, 2000
- Multiple Computer‐Automated structure evaluation program study of aquatic toxicity 1: GuppyEnvironmental Toxicology and Chemistry, 1999
- An Overview of Structure-Activity Relationships as an Alternative To Testing in Animals for Carcinogenicity, Mutagenicity, Dermal and Eye Irritation, and Acute Oral ToxicityToxicology and Industrial Health, 1988
- Analysis of the Registry of Toxic Effects of Chemical Substances (RTECS) Files and Conversion of the Data in These Files for Input to the Environmental Chemicals Data and Information Network (ECDIN)Journal of Chemical Information and Computer Sciences, 1978