A novel PHEX mutation associated with vitamin D-resistant rickets
Open Access
- 14 February 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Human Genome Variation
- Vol. 6 (1), 1-3
- https://doi.org/10.1038/s41439-019-0040-3
Abstract
X-linked hypophosphatemic rickets (XLH) is the most common form of hereditary rickets. Here, we present a case of XLH associated with a novel mutation in a phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX). PCR-direct sequencing revealed a novel PHEX mutation in exon 22, NM_000444.6(PHEX):c.2202del [p.Asn736Ilefs*4], near the 3′-UTR region encoding the COOH-terminal extracellular domain. In silico analysis indicated that a single mutation in N736 may have caused a significant change in higher-order protein structure and function.Keywords
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