Preparation and Thermosensitivity of Naturally Occurring Polypeptide Poly(γ‐glutamic acid) Derivatives Modified by Propyl Groups
- 13 April 2004
- journal article
- Published by Wiley in Macromolecular Bioscience
- Vol. 4 (4), 407-411
- https://doi.org/10.1002/mabi.200300073
Abstract
Poly(gamma-glutamic acid) (gamma-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(alpha-propyl gamma-glutamate) (gamma-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the gamma-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the gamma-PGA polymeric chains.Keywords
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