Trial of Roxithromycin in Subjects with Asthma and Serological Evidence of Infection withChlamydia pneumoniae
- 15 August 2001
- journal article
- clinical trial
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 164 (4), 536-541
- https://doi.org/10.1164/ajrccm.164.4.2011040
Abstract
An association has been reported between chronic infection with Chlamydia pneumoniae and the severity of asthma, and uncontrolled observations have suggested that treatment with antibiotics active against C. pneumoniae leads to an improvement in asthma control. We studied the effect of roxithromycin in subjects with asthma and immunoglobulin G (IgG) antibodies to C. pneumoniae ⩾ 1:64 and/or IgA antibodies ⩾ 1:16. A total of 232 subjects, from Australia, New Zealand, Italy, or Argentina, were randomized to 6 wk of treatment with roxithromycin 150 mg twice a day or placebo. At the end of 6 wk, the increase from baseline in evening peak expiratory flow (PEF) was 15 L/min with roxithromycin and 3 L/min with placebo (p = 0.02). With morning PEF, the increase was 14 L/min with roxithromycin and 8 L/min with placebo (NS). In the Australasian population, the increase in morning PEF was 18 L/min and 4 L/min, respectively (p = 0.04). At 3 mo and 6 mo after the end of treatment, differences between the two groups were smaller and not significant. Six weeks of treatment with roxithromycin led to improvements in asthma control but the benefit was not sustained. Further studies are necessary to determine whether the lack of sustained benefit is due to failure to eradicate C. pneumoniae. Keywords: asthma; Chlamydia pneumoniae; roxithromycin; randomized, controlled trialKeywords
This publication has 21 references indexed in Scilit:
- Chlamydia pneumoniae serological status is not associated with asthma in children or young adultsInternational Journal of Epidemiology, 2000
- Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthmaEuropean Respiratory Journal, 2000
- Montelukast Added to Inhaled Beclomethasone in Treatment of AsthmaAmerican Journal of Respiratory and Critical Care Medicine, 1999
- Chronic infection in the aetiology of atherosclerosis—focus on Chlamydia pneumoniaeAtherosclerosis, 1999
- Chlamydia pneumoniae and asthmaThorax, 1998
- Chronic Chlamydia pneumoniae infection and asthma exacerbations in childrenEuropean Respiratory Journal, 1998
- Quality of life in asthma clinical trials: comparison of salmeterol and salbutamol.American Journal of Respiratory and Critical Care Medicine, 1995
- The Association of Chlamydia pneumoniae Infection and Reactive Airway Disease in ChildrenArchives of Pediatrics & Adolescent Medicine, 1994
- Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. International Study Group.Thorax, 1993
- A New Respiratory Tract Pathogen: Chlamydia pneumoniae Strain TWARThe Journal of Infectious Diseases, 1990