Dissecting Japan's Dengue Outbreak in 2014
Open Access
- 3 February 2016
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 94 (2), 409-412
- https://doi.org/10.4269/ajtmh.15-0468
Abstract
Despite Japan's temperate climate, a dengue outbreak occurred in Tokyo for the first time in over 70 years in 2014. We dissected this dengue outbreak based on phylogenetic analysis, travel interconnectivity, and environmental drivers for dengue epidemics. Comparing the available dengue virus 1 (DENV1) E gene sequence from this outbreak with 3,282 unique DENV1 sequences in National Center for Biotechnology Information suggested that the DENV might have been imported from China, Indonesia, Singapore, or Vietnam. With travelers arriving into Japan, Guangzhou (China) may have been the source of DENV introduction, given that Guangzhou also reported a large-scale dengue outbreak in 2014. Coinciding with the 2014 outbreak, Tokyo's climate conditions permitted the amplification of Aedes vectors and the annual peak of vectorial capacity. Given suitable vectors and climate conditions in addition to increasing interconnectivity with endemic areas of Asia, Tokyo's 2014 outbreak did not come as a surprise and may foretell more to come.Keywords
This publication has 12 references indexed in Scilit:
- Estimating Air Travel–Associated Importations of Dengue Virus Into ItalyJournal of Travel Medicine, 2015
- Autochthonous Dengue Fever, Tokyo, Japan, 2014Emerging Infectious Diseases, 2015
- Vectorial Capacity of Aedes aegypti: Effects of Temperature and Implications for Global Dengue Epidemic PotentialPLOS ONE, 2014
- The 2012 dengue outbreak in Madeira: exploring the originsEurosurveillance, 2014
- RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogeniesBioinformatics, 2014
- Global temperature constraints on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmissionParasites & Vectors, 2014
- Epidemiology of dengue: past, present and future prospectsClinical Epidemiology, 2013
- Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegyptiProceedings of the National Academy of Sciences, 2011
- FastTree 2 – Approximately Maximum-Likelihood Trees for Large AlignmentsPLOS ONE, 2010
- MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transformNucleic Acids Research, 2002