Essential tremor and Parkinson's disease: Lack of a link
- 31 January 2011
- journal article
- viewpoint
- Published by Wiley in Movement Disorders
- Vol. 26 (3), 372-377
- https://doi.org/10.1002/mds.23509
Abstract
Background: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed. © 2011 Movement Disorder SocietyKeywords
This publication has 42 references indexed in Scilit:
- Rest tremor in advanced essential tremor: a post-mortem study of nine casesJournal of Neurology, Neurosurgery & Psychiatry, 2010
- Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brainsMovement Disorders, 2009
- Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based studyJournal of Neurology, Neurosurgery & Psychiatry, 2008
- Neuropathological changes in essential tremor: 33 cases compared with 21 controlsBrain, 2007
- Neuropathologic findings in essential tremorNeurology, 2006
- Essential Tremor Associated With Focal Nonnigral Lewy BodiesArchives of Neurology, 2005
- Essential tremor course and disabilityNeurology, 2004
- Clinicopathologic observations in essential tremorNeurology, 1991
- Essential (familial, hereditary) tremor: a case report.Journal of Neurology, Neurosurgery & Psychiatry, 1969
- Etudes anatomo-cliniques de syndromes hypercinétiques complexesEuropean Neurology, 1940