Human papillomavirus type 16 in vulvar carcinoma, vulvar intraepithelial neoplasia, and associated cervical neoplasia
- 31 July 1991
- journal article
- Published by Elsevier BV in Gynecologic Oncology
- Vol. 42 (1), 22-26
- https://doi.org/10.1016/0090-8258(91)90224-s
Abstract
Vulvar intraepithelial neoplasia (VIN) is becoming more widespread and the patients are becoming still younger. Although progression to invasive vulvar carcinoma is uncommon, local recurrences are frequent and about one-quarter of the patients have multicentric genital disease. The aim of the present study was to search for a possible significant association of human papillomavirus (HPV) infection with vulvar carcinoma, recurrences, and multicentric disease. We used the polymerase chain reaction to examine vulvar and cervical biopsies from 43 patients with vulvar neoplasia for HPV type 16, which is the subtype most often detected in genital malignant or premalignant lesions. HPV 16 DNA sequences were found in 14 of 24 (58%) vulvar squamous carcinomas and in 15 of 19 (79%) VIN lesions. Nine patients (21%) had associated cervical neoplasia and six of these harbored HPV 16 in both lesions. Patients with recurrent intraepithelial neoplasia had a significantly higher incidence of HPV 16-positive lesions. No association was found with regard to the occurrence of multicentric disease or risk of malignant progressionKeywords
This publication has 18 references indexed in Scilit:
- Lichen sclerosus, invasive squamous cell carcinoma, and human papillomavirusAmerican Journal of Obstetrics and Gynecology, 1990
- Role of human papillomavirus in the pathogenesis of genital tract warts and cancerGynecologic Oncology, 1990
- Prevalence of human papillomavirus types 11, 16 and 18 in cervical swabs. A study of 1362 pregnant womenEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 1990
- Nachweis von humaner Papilloma-Virus(HPV)-DNA in VulvakarzinomenGeburtshilfe und Frauenheilkunde, 1988
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988
- Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction.The Journal of Experimental Medicine, 1988
- Human Papillomavirus-Associated Early Vulvar Neoplasia Investigated by In Situ HybridizationThe American Journal of Surgical Pathology, 1987
- Human papillomavirus type 16 DNA sequenceVirology, 1985
- Intraepithelial neoplasia in the vulvar regionGynecologic Oncology, 1985
- Double primary epidermoid carcinoma of the vulva and cervixGynecologic Oncology, 1980