A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit
- 1 October 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 341 (6244), 752-754
- https://doi.org/10.1038/341752a0
Abstract
Fc receptors for immunoglobulins are found on many immune cells and trigger essential functions of the immune defence system. With the exception of the high-affinity receptor for immunoglobulin E (Fc epsilon RI), these receptors were thought to consist of single polypeptides. Fc epsilon RI is a tetrameric complex of one alpha-subunit, one beta-subunit and two gamma-subunits. Here we report the cloning of a polypeptide identical to the gamma-chains of Fc epsilon RI, from mouse macrophages that do not express this receptor. Biosynthetic labelling and gene transfer together show that these gamma-chains associate with one of the macrophage receptors (Fc gamma RIIa). The human homologue, Fc gamma RIII (CD16), from natural killer cells is also expected to associate with gamma-chains. It is possible that these gamma-chains and the homologous zeta-chains of the T-cell antigen receptor belong to a new family of related proteins which share a common role in the signal transducing pathway.Keywords
This publication has 20 references indexed in Scilit:
- Complete structure of the mouse mast cell receptor for IgE (Fc ϵ RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cellsPublished by Elsevier BV ,1989
- Antibody-cell interactions: Fc receptorsCell, 1989
- Complete structure and expression in transfected cells of high affinity IgE receptorNature, 1989
- Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E.Proceedings of the National Academy of Sciences of the United States of America, 1988
- Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.Proceedings of the National Academy of Sciences of the United States of America, 1988
- Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptorNucleic Acids Research, 1988
- A cDNA presumptively coding for the .alpha. subunit of the receptor with high affinity for immunoglobulin EBiochemistry, 1987
- Formation of functional asialoglycoprotein receptor after transfection with cDNAs encoding the receptor proteins.Proceedings of the National Academy of Sciences of the United States of America, 1986
- Structural Heterogeneity and Functional Domains of Murine Immunoglobulin G Fc ReceptorsScience, 1986
- A previously unrecognized subunit of the receptor for immunoglobulinBiochemistry, 1983