Association of Hemoglobin Levels With Clinical Outcomes in Acute Coronary Syndromes
Top Cited Papers
- 26 April 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 111 (16), 2042-2049
- https://doi.org/10.1161/01.cir.0000162477.70955.5f
Abstract
Background— In the setting of an acute coronary syndrome (ACS), anemia has the potential to worsen myocardial ischemia; however, data relating anemia to clinical outcomes in ACS remain limited. Methods and Results— We examined the association between baseline hemoglobin values and major adverse cardiovascular events through 30 days in 39 922 patients enrolled in clinical trials of ACS. After adjustment for differences in baseline characteristics and index hospitalization treatments, a reverse J-shaped relationship between baseline hemoglobin values and major adverse cardiovascular events was observed. In patients with ST-elevation myocardial infarction, when those with hemoglobin values between 14 and 15 g/dL were used as the reference, cardiovascular mortality increased as hemoglobin levels fell below 14 g/dL, with an adjusted OR of 1.21 (95% CI 1.12 to 1.30, P17 g/dL also had ex...This publication has 28 references indexed in Scilit:
- Prognostic Implication of Anemia on In-Hospital Outcomes After Percutaneous Coronary InterventionCirculation, 2004
- Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: Results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic urialJournal of the American College of Cardiology, 2003
- Anemia Is Common in Heart Failure and Is Associated With Poor OutcomesCirculation, 2003
- Effect of anemia on 1-year mortality in patients with acute myocardial infarctionAmerican Heart Journal, 2002
- Acute Dilutional Anemia and Critical Left Anterior Descending Coronary Artery Stenosis Impairs End Organ Oxygen DeliveryThe Journal of Trauma and Acute Care Surgery, 1996
- Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 4 trialJournal of the American College of Cardiology, 1994
- Hematocrit and the risk of cardiovascular disease—The Framingham Study: A 34-year follow-upAmerican Heart Journal, 1994
- Markedly decreased coronary blood flow in secondary polycythemiaAmerican Heart Journal, 1992
- Effect of acute anemia on experimental myocardial ischemiaThe American Journal of Cardiology, 1973
- Clinical, Haemodynamic, Rheological, and Biochemical Findings in 126 Patients with Intermittent ClaudicationBMJ, 1973