Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle
- 4 September 2013
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 72 (1), 8-19
- https://doi.org/10.1002/mrm.24917
Abstract
The relationship between fat fractions (FFs) determined based on multiple TE, unipolar gradient echo images and (1) H magnetic resonance spectroscopy (MRS) was evaluated using different models for fat-water decomposition, signal-to-noise ratios, and excitation flip angles. A combination of single-voxel proton spectroscopy ((1) H-MRS) and gradient echo imaging was used to determine muscle FFs in both normal and dystrophic muscles. In order to cover a large range of FFs, the soleus and vastus lateralis muscles of 22 unaffected control subjects, 16 subjects with collagen VI deficiency (COL6), and 71 subjects with Duchenne muscular dystrophy (DMD) were studied. (1) H-MRS-based FF were corrected for the increased muscle (1) H2 O T1 and T2 values observed in dystrophic muscles. Excellent agreement was found between coregistered FFs derived from gradient echo images fit to a multipeak model with noise bias correction and the relaxation-corrected (1) H-MRS FFs (y = 0.93x + 0.003; R(2) = 0.96) across the full range of FFs. Relaxation-corrected (1) H-MRS FFs and imaging-based FFs were significantly elevated (P < 0.01) in the muscles of COL6 and DMD subjects. FFs, T2 , and T1 were all sensitive to muscle involvement in dystrophic muscle. MRI offered an additional advantage over single-voxel spectroscopy in that the tissue heterogeneity in FFs could be readily determined.This publication has 61 references indexed in Scilit:
- Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular DystrophyPhysical Medicine and Rehabilitation Clinics of North America, 2012
- Evidence‐based path to newborn screening for duchenne muscular dystrophyAnnals of Neurology, 2012
- Canine models of Duchenne muscular dystrophy and their use in therapeutic strategiesMammalian Genome, 2012
- Congenital Muscular Dystrophies: A Brief ReviewSeminars in Pediatric Neurology, 2011
- Impending therapies for Duchenne muscular dystrophyCurrent Opinion in Neurology, 2011
- The collagen VI-related myopathies: muscle meets its matrixNature Reviews Neurology, 2011
- Congenital Muscular Dystrophies: Toward Molecular Therapeutic InterventionsCurrent Neurology and Neuroscience Reports, 2010
- Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary careThe Lancet Neurology, 2010
- Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial managementThe Lancet Neurology, 2010
- Dystrophin: The protein product of the duchenne muscular dystrophy locusCell, 1987