New Organoselenium Compounds Active against Pathogenic Bacteria, Fungi and Viruses
- 1 January 2008
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 56 (10), 1423-1427
- https://doi.org/10.1248/cpb.56.1423
Abstract
Different N-substituted benzisoselenazol-3(2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV)), in vitro. Most of them exhibited high activity against viruses (HSV-1, EMCV) and gram-positive bacteria strains (S. aureus, S. simulans), while their activity against gram-negative bacteria strains (E. coli, P. aeruginosa, K. pneumoniae) was substantially lower. Some of tested compounds were active against yeast C. albicans and filamentous fungus A. niger.Keywords
This publication has 10 references indexed in Scilit:
- Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and propertiesIl Farmaco, 2004
- Organoselenium Compounds as Potential Therapeutic and Chemopreventive Agents: A ReviewCurrent Medicinal Chemistry, 2004
- The reactions of 2-(chloroseleno)benzoyl chloride with nucleophilesTetrahedron, 2002
- Chemistry of Biologically Important Synthetic Organoselenium CompoundsChemical Reviews, 2001
- Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activityChemical Society Reviews, 2000
- Intramolecular Homolytic Substitution with Amidyl Radicals: A Free-Radical Synthesis of Ebselen and Related AnaloguesThe Journal of Organic Chemistry, 1997
- Molecular actions of Ebselen—an antiinflammatory antioxidantGeneral Pharmacology: The Vascular System, 1995
- Aromatic and Azaaromatic Diselenides, Benzisoselenazolones and Related Compounds as Immunomodulators Active in Humans: Synthesis and PropertiesEuropean Journal of Organic Chemistry, 1993
- Ebselen, a selenoorganic compound as glutathione peroxidase mimicFree Radical Biology & Medicine, 1993
- Über selenhaltige aromatische Verbindungen (VI)Berichte der deutschen chemischen Gesellschaft (A and B Series), 1924