Coated-platelets predict stroke at 30 days following TIA
- 11 July 2017
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 89 (2), 125-128
- https://doi.org/10.1212/wnl.0000000000004090
Abstract
Objective: To examine the potential for coated-platelets, a subset of highly procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, for predicting stroke at 30 days in patients with TIA. Methods: Consecutive patients with TIA were enrolled and followed up prospectively. ABCD2 scores were obtained for each patient. Coated-platelet levels, reported as percent of cells converted to coated-platelets, were determined at baseline. The primary endpoint was the occurrence of stroke at 30 days. Receiver operator characteristic (ROC) analysis was used to calculate area under the curve (AUC) values for a model including coated-platelets to predict incident stroke at 30 days. Results: A total of 171 patients with TIA were enrolled, and 10 strokes were observed at 30 days. A cutoff of 51.1% for coated-platelet levels yielded a sensitivity of 0.80 (95% confidence interval [CI] 0.55–1.0), specificity of 0.73 (95% CI 0.66–0.80), positive predictive value of 0.16 (95% CI 0.06–0.26), and negative predictive value of 0.98 (95% CI 0.96–1.0). The adjusted hazard ratio of incident stroke in patients with coated-platelet levels ≥51.1% was 10.72 compared to those with levels p = 0.01). Conclusions: These findings suggest a role for coated-platelets in risk stratification for stroke at 30 days after TIA.This publication has 10 references indexed in Scilit:
- Clopidogrel With Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) TrialCirculation, 2015
- Elevated coated-platelets in symptomatic large-artery stenosis patients are associated with early stroke recurrencePlatelets, 2013
- Higher Coated-Platelet Levels are Associated with Stroke Recurrence following Nonlacunar Brain InfarctionJournal of Cerebral Blood Flow & Metabolism, 2012
- Higher coated-platelet levels are associated with chronic hypertension in patients with transient ischemic attackPlatelets, 2012
- Patients With Transient Ischemic Attack With ABCD 2 2 ≥4Stroke, 2012
- Coated-platelet levels are elevated in patients with transient ischemic attackTranslational Research, 2011
- Definition and Evaluation of Transient Ischemic AttackStroke, 2009
- Coated‐platelets in ischemic stroke: differences between lacunar and cortical strokeJournal of Thrombosis and Haemostasis, 2008
- Validation and refinement of scores to predict very early stroke risk after transient ischaemic attackThe Lancet, 2007
- REVIEW ARTICLE: Coated-platelets: an emerging component of the procoagulant responseJournal of Thrombosis and Haemostasis, 2005