Applications of arterial spin labeled MRI in the brain
Top Cited Papers
Open Access
- 13 January 2012
- journal article
- review article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 35 (5), 1026-1037
- https://doi.org/10.1002/jmri.23581
Abstract
Perfusion provides oxygen and nutrients to tissues and is closely tied to tissue function while disorders of perfusion are major sources of medical morbidity and mortality. It has been almost two decades since the use of arterial spin labeling (ASL) for noninvasive perfusion imaging was first reported. While initial ASL magnetic resonance imaging (MRI) studies focused primarily on technological development and validation, a number of robust ASL implementations have emerged, and ASL MRI is now also available commercially on several platforms. As a result, basic science and clinical applications of ASL MRI have begun to proliferate. Although ASL MRI can be carried out in any organ, most studies to date have focused on the brain. This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care. J. Magn. Reson. Imaging 2012;35:1026‐1037.Keywords
This publication has 129 references indexed in Scilit:
- Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: A longitudinal perfusion fMRI studyDrug and Alcohol Dependence, 2011
- Test–retest reliability of arterial spin labeling with common labeling strategiesJournal of Magnetic Resonance Imaging, 2011
- Estimation of perfusion and arterial transit time in myocardium using free‐breathing myocardial arterial spin labeling with navigator‐echoMagnetic Resonance in Medicine, 2010
- Modified pulsed continuous arterial spin labeling for labeling of a single arteryMagnetic Resonance in Medicine, 2010
- Estimation of labeling efficiency in pseudocontinuous arterial spin labelingMagnetic Resonance in Medicine, 2010
- The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test–retest studyNeuroImage, 2010
- Skeletal Muscle Microvascular Flow in Progressive Peripheral Artery Disease: Assessment With Continuous Arterial Spin-Labeling Perfusion Magnetic Resonance ImagingJournal of the American College of Cardiology, 2009
- Arterial spin labeling perfusion MRI in pediatric arterial ischemic stroke: Initial experiencesJournal of Magnetic Resonance Imaging, 2009
- Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsyEpilepsy Research, 2008
- Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fieldsMagnetic Resonance in Medicine, 2008