Performance of the dynamic single photon emission computed tomography (dSPECT) method for decreasing or increasing activity changes
- 7 November 2000
- journal article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 45 (12), 3525-3543
- https://doi.org/10.1088/0031-9155/45/12/302
Abstract
Radionuclide imaging is now widely used whenever functional information is required. We present a new approach to dynamic SPECT imaging (dSPECT method) that uses a single slow rotation of a conventional camera and allows us to reconstruct a series of 3D images corresponding to the radiotracer distribution in the body at various times. Using simulations of various camera configurations and acquisition protocols, we have shown that this method is able to reconstruct washout half-lives with an accuracy greater than 90% when used with triple-head SPECT cameras. Accuracy decreases when using fewer camera heads, but dual-head geometries still give an accuracy greater than 80% for short and 90% for long half-lives and about 50-75% for single-head systems. Dynamic phantom experiments have yielded similar results. Presence of attenuation and background activity does not affect the accuracy of the dSPECT reconstructions. In all situations investigated satisfactory dynamic images were produced. A preliminary normal volunteer study measuring renal function was performed. The reconstructed dynamic images may be presented as a three-dimensional movie showing movement of the tracer through the kidneys and the measurement of the regional renal function can be performed. The time-activity curves determined from this dSPECT data are very similar to those obtained from dynamic planar scans.Keywords
This publication has 12 references indexed in Scilit:
- An EM algorithm for dynamic SPECTIEEE Transactions on Medical Imaging, 1999
- Dynamic SPECT imaging using a single camera rotation (dSPECT)IEEE Transactions on Nuclear Science, 1999
- Kinetic parameter estimation from attenuated SPECT projection measurementsIEEE Transactions on Nuclear Science, 1998
- Dynamic heart-in-thorax phantom for functional SPECTIEEE Transactions on Nuclear Science, 1997
- Direct reconstruction of functional parameters for dynamic SPECTIEEE Transactions on Nuclear Science, 1995
- Dynamic cardiac SPECT computer simulations for teboroxime kineticsIEEE Transactions on Nuclear Science, 1994
- Model-based estimation for dynamic cardiac studies using ECTIEEE Transactions on Medical Imaging, 1994
- Efficacy of 15-(123I)-p-iodophenyl pentadecanoic acid (IPPA) in assessing myocardial metabolism in a model of reversible global ischemiaEuropean Journal of Nuclear Medicine and Molecular Imaging, 1988
- Dynamic PET Data AnalysisJournal of Computer Assisted Tomography, 1986
- Serial measurement of regional cerebral blood flow in patients with SAH using 133Xe inhalation and emission computerized tomographyJournal of Neurosurgery, 1984