Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population
- 10 April 2014
- Vol. 100 (12), 938-943
- https://doi.org/10.1136/heartjnl-2013-305099
Abstract
Objective The effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular system remains controversial. We investigated the independent contribution of NAFLD to cardiovascular structure and function in the general population. Methods A total of 1886 participants without known cardiovascular disease were enrolled from the Korean Genome Epidemiology Study. The participants were divided into four groups, based on the presence of NAFLD, metabolic syndrome (MetS), neither or both. NAFLD was diagnosed by CT. Changes in cardiovascular structure and function were assessed by tissue Doppler imaging (TDI) echocardiography, carotid ultrasound and brachial-ankle pulse wave velocity (baPWV). Results In multivariate analyses, subjects with both NAFLD and MetS had a higher E/Ea ratio and baPWV, as well as a lower TDI Ea velocity (all pConclusions NAFLD was associated with early alterations of cardiovascular system, independent of established cardiovascular risk factors and MetS.Keywords
This publication has 29 references indexed in Scilit:
- Non‐alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groupsJournal of Gastroenterology and Hepatology, 2013
- Nonalcoholic fatty liver disease is associated with coronary artery calcificationHepatology, 2012
- Hepatic Steatosis, Obesity, and the Metabolic Syndrome Are Independently and Additively Associated With Increased Systemic InflammationArteriosclerosis, Thrombosis, and Vascular Biology, 2011
- Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: A narrative review and clinical perspective of prospective dataHepatology, 2010
- Hepatic Steatosis and Subclinical Cardiovascular Disease in a Cohort Enriched for Type 2 Diabetes: The Diabetes Heart StudyThe American Journal of Gastroenterology, 2008
- Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic reviewJournal of Hepatology, 2008
- γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease MortalityCirculation, 2005
- Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver diseaseHepatology, 2005
- Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicityHepatology, 2004
- Association of nonalcoholic fatty liver disease with insulin resistanceAmerican Journal Of Medicine, 1999