The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg2
Open Access
- 1 July 2011
- journal article
- Published by Elsevier BV
- Vol. 286 (30), 26298-26307
- https://doi.org/10.1074/jbc.m111.244798
Abstract
No abstract availableThis publication has 38 references indexed in Scilit:
- Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and InsigsPublished by Elsevier BV ,2004
- Structural Control of Endoplasmic Reticulum-associated DegradationPublished by Elsevier BV ,2004
- Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and GeranylgeraniolPublished by Elsevier BV ,2003
- Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterolsProceedings of the National Academy of Sciences of the United States of America, 2002
- Crucial Step in Cholesterol Homeostasis: Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ERCell, 2002
- Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in DrosophilaScience, 2002
- The sterol-sensing domain: multiple families, a unique role?Trends in Genetics, 2002
- An Oxysterol-derived Positive Signal for 3-Hydroxy- 3-methylglutaryl-CoA Reductase Degradation in YeastPublished by Elsevier BV ,2001
- Endoplasmic Reticulum Degradation Requires Lumen to Cytosol SignalingThe Journal of cell biology, 2000
- [8] Measuring protein degradation with green fluorescent proteinMethods in Enzymology, 1999