Associative Conditioning of Single Sensory Neurons Suggests a Cellular Mechanism for Learning
- 28 January 1983
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4583), 405-408
- https://doi.org/10.1126/science.6294834
Abstract
A cellular analog of associative learning has been demonstrated in individual sensory neurons of the tail withdrawal reflex of Aplysia. Sensory cells activated by intracellular current injection shortly before a sensitizing shock to the animal's tail display significantly more facilitation of their monosynaptic connections to a tail motor neuron than cells trained either with intracellular stimulation unpaired to tail shock or with tail shock alone. This associative effect is acquired rapidly and is expressed as a temporally specific amplification of heterosynaptic facilitation. The results suggest that activity-dependent neuromodulation may be a mechanism underlying associative information storage and point to aspects of subcellular processes that might be involved in the formation of neural associations.This publication has 24 references indexed in Scilit:
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