High-Resolution CT Findings in Fibrotic Idiopathic Interstitial Pneumonias With Little Honeycombing: Serial Changes and Prognostic Implications
- 1 November 2012
- journal article
- Published by American Roentgen Ray Society in American Journal of Roentgenology
- Vol. 199 (5), 982-989
- https://doi.org/10.2214/ajr.11.8192
Abstract
OBJECTIVE. This retrospective study evaluates serial changes of lung abnormalities on high-resolution CT (HRCT) and clarifies prognostic determinants among CT findings in fibrotic idiopathic interstitial pneumonias (IIPs) with little honeycombing. MATERIALS AND METHODS. We enrolled 154 patients with a histologic diagnosis of a fibrotic IIP (< 5% honeycombing on CT) who were followed clinically for at least 2 years. One hundred one patients had usual interstitial pneumonia (UIP) and 53 had fibrotic nonspecific interstitial pneumonia (NSIP). On baseline CT, the extent and distribution of lung abnormalities were visually assessed, and serial CT scans were evaluated with a follow-up period of at least 6 months (n = 132). RESULTS. Significant differences were noted in the extent of reticulation and ground-glass opacification (GGO) between the UIP and fibrotic NSIP groups (p < 0.001). On serial scans, honeycombing (5% in UIP and 3% in fibrotic NSIP; p = 0.08) and reticulation (3% in UIP and 8% in fibrotic NSIP;...This publication has 20 references indexed in Scilit:
- Prognostic Determinants among Clinical, Thin-Section CT, and Histopathologic Findings for Fibrotic Idiopathic Interstitial Pneumonias: Tertiary Hospital StudyRadiology, 2008
- Fleischner Society: Glossary of Terms for Thoracic ImagingRadiology, 2008
- Acute exacerbation of interstitial pneumonia following surgical lung biopsyRespiratory Medicine, 2006
- Idiopathic Interstitial Pneumonias: CT FeaturesRadiology, 2005
- Prognostic Implications of Histologic Patterns in Multiple Surgical Lung Biopsies From Patients With Idiopathic Interstitial PneumoniasSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2004
- Radiologic Findings Are Strongly Associated With a Pathologic Diagnosis of Usual Interstitial PneumoniaSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2003
- Clinical significance of histological classification of idiopathic interstitial pneumonia.European Respiratory Journal, 2002
- American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial PneumoniasAmerican Journal of Respiratory and Critical Care Medicine, 2002
- Utility of a Lung Biopsy for the Diagnosis of Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2001
- Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 1998