β-Cell death during progression to diabetes
- 1 December 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 414 (6865), 792-798
- https://doi.org/10.1038/414792a
Abstract
The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.Keywords
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