Meningococcal Meningitis Surveillance in the African Meningitis Belt, 2004–2013
Open Access
- 9 November 2015
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 61 (suppl_5), S410-S415
- https://doi.org/10.1093/cid/civ597
Abstract
Background. An enhanced meningitis surveillance network was established across the meningitis belt of sub-Saharan Africa in 2003 to rapidly collect, disseminate, and use district weekly data on meningitis incidence. Following 10 years’ experience with enhanced surveillance that included the introduction of a group A meningococcal conjugate vaccine, PsA-TT (MenAfriVac), in 2010, we analyzed the data on meningitis incidence and case fatality from countries reporting to the network. Methods. After de-duplication and reconciliation, data were extracted from the surveillance bulletins and the central database held by the World Health Organization Inter-country Support Team in Burkina Faso for countries reporting consistently from 2004 through 2013 (Benin, Burkina Faso, Chad, Democratic Republic of Congo, Ghana, Côte d'Ivoire, Mali, Niger, Nigeria, Togo). Results. The 10 study countries reported 341 562 suspected and confirmed cases over the 10-year study period, with a marked peak in 2009 due to a large epidemic of group A Neisseria meningitidis (NmA) meningitis. Case fatality was lowest (5.9%) during this year. A mean of 71 and 67 districts annually crossed the alert and epidemic thresholds, respectively. The incidence rate of NmA meningitis fell >10-fold, from 0.27 per 100 000 in 2004–2010 to 0.02 per 100 000 in 2011–2013 (P < .0001). Conclusions. In addition to supporting timely outbreak response, the enhanced meningitis surveillance system provides a global overview of the epidemiology of meningitis in the region, despite limitations in data quality and completeness. This study confirms a dramatic fall in NmA incidence after the introduction of PsA-TT.Keywords
This publication has 13 references indexed in Scilit:
- Continuing Effectiveness of Serogroup A Meningococcal Conjugate Vaccine, Chad, 2013Emerging Infectious Diseases, 2015
- Meningococcal disease control in countries of the African meningitis belt, 2013.2014
- Effect of a serogroup A meningococcal conjugate vaccine (PsA–TT) on serogroup A meningococcal meningitis and carriage in Chad: a community studyThe Lancet, 2013
- Serogroup A meningococcal conjugate vaccination in Burkina Faso: analysis of national surveillance dataThe Lancet Infectious Diseases, 2012
- Meningococcal vaccines: WHO position paper, November 2011.2011
- Sequelae due to bacterial meningitis among African children: a systematic literature reviewBMC Medicine, 2009
- Potential of environmental models to predict meningitis epidemics in AfricaTropical Medicine & International Health, 2006
- Enhanced surveillance of epidemic meningococcal meningitis in Africa: a three-year experience.2005
- Detecting meningococcal meningitis epidemics in highly-endemic African countries.2000
- Meningococcal meningitis in AfricaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1999