Severe Acute Respiratory Syndrome Coronavirus on Hospital Surfaces
- 1 September 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 39 (5), 652-657
- https://doi.org/10.1086/422652
Abstract
Background. Health care workers continued to contract severe acute respiratory syndrome (SARS), even after barrier precautions were widely implemented. Methods. We explored the possible contribution of contaminated hospital surfaces to SARS transmission by swabbing surfaces in 2 hospitals and testing the swab samples by reverse-transcriptase polymerase chain reaction (RT-PCR) and viral culture. Results. Twenty-six of 94 swab samples tested positive for viral RNA. Swab samples of respiratory secretions from each of the 4 patients examined tested positive by RT-PCR, as were 12 of 43 swabs from patient rooms and 10 of 47 swabs from other parts of the hospital, including the computer mouses at 2 nursing stations and the handrail of the public elevator. Specimens from areas with patients with SARS in the most infectious phase of illness (days 5–15 after onset) were more likely to be RNA positive than were swab specimens from elsewhere (24 of 63 samples vs. 2 of 31 samples; P = .001). All cultures showed no growth. Conclusions. Although the viruses identified may have been noninfectious, health care workers should be aware that SARS coronavirus can contaminate environmental surfaces in the hospital, and fomites should be considered to be a possible mode of transmission of SARS.Keywords
This publication has 15 references indexed in Scilit:
- Transmission of the Severe Acute Respiratory Syndrome on AircraftNew England Journal of Medicine, 2003
- Severe acute respiratory syndrome--Taiwan, 2003.2003
- Cluster of severe acute respiratory syndrome cases among protected health-care workers--Toronto, Canada, April 2003.2003
- A Novel Coronavirus Associated with Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS)The Lancet, 2003
- Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective studyThe Lancet, 2003
- Update: Outbreak of severe acute respiratory syndrome--worldwide, 2003.2003
- An Outbreak of Diarrhea in a Neonatal Medium Care Unit Caused by a Novel Strain of Rotavirus: Investigation Using Both Epidemiologic and Microbiological MethodsInfection Control & Hospital Epidemiology, 2002
- Survival of human coronaviruses 229E and OC43 in suspension and after drying onsurfaces: a possible source ofhospital-acquired infectionsJournal of Hospital Infection, 2000
- Outbreak Investigation of Nosocomial Enterobacter cloacae bacteraemia in a Neonatal Intensive Care UnitScandinavian Journal of Infectious Diseases, 2000