Pathophysiology and Pharmacology of GABAA Receptors
- 31 December 2004
- book chapter
- other
- Published by Springer Science and Business Media LLC in Handbook of Experimental Pharmacology
- No. 169,p. 225-247
- https://doi.org/10.1007/3-540-28082-0_9
Abstract
By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective GABAA receptor subtypes, therefore, provide new opportunities not only for understanding GABA-dependent pathophysiologies but also for targeting of selective neuronal circuits by drugs. The pharmacological relevance of GABAA receptor subtypes is increasingly being recognized. A new central nervous system pharmacology is on the horizon. The development of anxiolytic drugs devoid of sedation and of agents that enhance hippocampus-dependent learning and memory has become a novel and highly selective therapeutic opportunity.This publication has 124 references indexed in Scilit:
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