Self-powered deep brain stimulation via a flexible PIMNT energy harvester
- 17 June 2015
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Energy & Environmental Science
- Vol. 8 (9), 2677-2684
- https://doi.org/10.1039/c5ee01593f
Abstract
Deep brain stimulation (DBS) is widely used for neural prosthetics and brain–computer interfacing. Thus far in vivo implantation of a battery has been a prerequisite to supply the necessary power. Although flexible energy harvesters have recently emerged as alternatives to batteries, they generate insufficient energy for operating brain stimulation. Herein, we report a high performance flexible piezoelectric energy harvester by enabling self-powered DBS in mice. This device adopts an indium modified crystalline Pb(In1/2Nb1/2)O3–Pb(Mg1/3Nb2/3)O3–PbTiO3 (PIMNT) thin film on a plastic substrate to transform tiny mechanical motions to electricity. With slight bending, it generates an extremely high current reaching 0.57 mA, which satisfies the high threshold current for real-time DBS of the motor cortex and thereby could efficiently induce forearm movements in mice. The PIMNT based flexible energy harvester could open a new avenue for future in vivo healthcare technology using self-powered biomedical devices.Keywords
Funding Information
- National Research Foundation of Korea (2011-0028772, 2014R1A2A1A12067558, CISS-2012M3A6A6054193)
This publication has 46 references indexed in Scilit:
- Flexible Piezoelectric Thin‐Film Energy Harvesters and Nanosensors for Biomedical ApplicationsAdvanced Healthcare Materials, 2014
- Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragmProceedings of the National Academy of Sciences, 2014
- Risks of common complications in deep brain stimulation surgery: management and avoidanceJournal of Neurosurgery, 2014
- Deep Brain Stimulation for EpilepsyNeurotherapeutics, 2008
- A Randomized Trial of Deep-Brain Stimulation for Parkinson's DiseaseNew England Journal of Medicine, 2006
- DEEP BRAIN STIMULATIONAnnual Review of Neuroscience, 2006
- Deep Brain Stimulation for Treatment-Resistant DepressionNeuron, 2005
- Deep brain stimulationCell and tissue research, 2004
- Cardiac Pacemaker Infection: Surgical Management With and Without Extracorporeal CirculationThe Annals of Thoracic Surgery, 1997
- Deep brain stimulation for essential tremorNeurology, 1996