Should we use carbohydrate deficient transferrin as a marker for alcohol abusers?
- 1 July 2004
- journal article
- Published by Springer Science and Business Media LLC in Indian Journal of Clinical Biochemistry
- Vol. 19 (2), 36-44
- https://doi.org/10.1007/bf02894255
Abstract
Carbohydrate deficient transferrin (CDT) is one of the conventional markers for chronic alcohol consumption, is used by researchers and clinicians. A number of enzymes are affected by ethanol intake. The induction or inhibition of sialyl transferase and plasma sialidase may be involved in the CDT level elevation. An alteration of protein transport during post-translational modification could be a primary mechanism in the impairment of protein metabolism associated with chronic alcohol abuse. Transferrin being a steroid responsive protein, sex-based hormonal variations might contribute to the lower sensitivity of CDT. Varying hormonal statuses such as pregnancy, use of contraceptives, menopause/ menstrual cycle can alter iron homeostasis in women. CDT levels are markedly affected by iron homeostasis. Several CDT assay methods appeared promising, but it is not readily apparent which technique is the most accurate. Moreover, false-positive results of CDT have been reported in non-alcohol related hepatic failure and in rare conditions. Therefore clinical interpretation of CDT needs careful assessment in patients with alcohol-related or non-alcohol-related health disorders.Keywords
This publication has 73 references indexed in Scilit:
- Effect of Hormone Balance on Carbohydrate-Deficient Transferrin and Gamma-Glutamyltransferase in Female Social DrinkersAlcohol: Clinical and Experimental Research, 2000
- Carbohydrate-Deficient Transferrin-A Valid Marker of Alcoholism in Population Studies? Results from the Copenhagen City Heart StudyAlcohol: Clinical and Experimental Research, 1995
- Carbohydrate-Deficient Transferrin as an Alcohol Marker among Female Heavy Drinkers: A Population-Based StudyAlcohol: Clinical and Experimental Research, 1994
- Carbohydrate‐Deficient Transferrin and γ‐Glutamyltransferase as Markers of Heavy Alcohol Consumption: Gender DifferencesAlcohol: Clinical and Experimental Research, 1994
- A Correlational Study of Carbohydrate‐Deficient Transferrin Values and Alcohol Consumption among Hispanic College StudentsAlcohol: Clinical and Experimental Research, 1994
- Carbohydrate-Deficient Transferrin During 3 Weeks' Heavy Alcohol ConsumptionAlcohol: Clinical and Experimental Research, 1994
- Purification of Isotransferrins by Concanavalin A Sepharose Chromatography and Preparative Isoelectric Focusingcclm, 1994
- Carbohydrate-deficient glycoprotein syndromes: Peculiar group of new disordersPediatric Neurology, 1993
- Effects of Chronic Ethanol on Enzymes Regulating Sialylation and Desialylation of Transferrin in RatsAlcohol: Clinical and Experimental Research, 1993
- Transferrin GlycansAlcohol: Clinical and Experimental Research, 1984