Interindividual Variation in Binding of Benzo[ a ]pyrene to DNA in Cultured Human Bronchi
- 3 December 1976
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 194 (4269), 1067-1069
- https://doi.org/10.1126/science.982061
Abstract
The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.Keywords
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