Structural and functional characteristics of the microcirculation in neoplasms
- 1 June 1975
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 116 (2), 65-72
- https://doi.org/10.1002/path.1711160202
Abstract
The microcirculation in a transplantable rat fibrosarcoma was investigated. The vasculature of the neoplasm consisted of irregular channels lined by plump endothelium which displayed mainly pentalaminar although a few heptalaminar junctions were also found. Few pericytes surround the endothelial layer while the basement-membrane varied in thickness and was often duplicated and triplicated. Challenge with histamine resulted in increased permeability in comparison with normal connective tissues similarly treated. The increased permeability was accompanied by the formation of interendothelial gaps in these irregular vascular channels. Carrageenan induced a leucocytic exudate in the neoplasm which, apart from an increase in the mononuclear concentration 2 wk after injection, varied little from normal connective tissues. It is concluded that the majority of vascular channels in this neoplasm bear some structural and functional relationship to small venules.Keywords
This publication has 10 references indexed in Scilit:
- TUMOR ANGIOGENESISThe Journal of cell biology, 1972
- The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcomaThe Journal of Pathology, 1972
- ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESISThe Journal of Experimental Medicine, 1971
- ENDOTHELIAL CONTRACTION INDUCED BY HISTAMINE-TYPE MEDIATORSThe Journal of cell biology, 1969
- The ultrastructure of mammalian arterioles and precapillary sphinctersJournal of Ultrastructure Research, 1967
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966
- Vascular Relationships of Tumor and Host*Advances In Radiation Therapy, 1964
- Some Aspects of the Microcirculation of a Transplantable Experimental TumorRadiology, 1961
- Electron microscopic studies of brain tumorsNeurology, 1960
- Determination of Evans Blue Dye in Blood and Tissues.Experimental Biology and Medicine, 1956