Characterization of the effects of pancreatic polypeptide in the regulation of energy balance

Abstract

Obesity is increasingly prevalent and an important public health problem in the world, particularly in developed societies. In the United States, more than half of adults are overweight. 1 x 1 Allison, D.B., Fontaine, K.R., Manson, J.E., Stevens, J., and Vanltallie, T.B. Annual deaths attributable to obesity in the United States. JAMA. 1999; 282: 1530–1538 Crossref | PubMed | Scopus (1388) | Google Scholar See all References , 2 x 2 Braddon, F.E., Rodgers, B., Wadsworth, M.E., and Davies, J.M. Onset of obesity in a 36 year birth cohort study. BMJ. 1986; 293: 299–303 Crossref | PubMed | Scopus (227) | Google Scholar See all References Obesity is associated with an increased risk of various related disorders, including diabetes, hyperlipidemia, liver disease, cardiovascular disease, pulmonary disease, osteoarthritis, and certain forms of cancer. Consequently, a huge effort is currently being directed toward developing antiobesity drugs.