The Guanine Nucleotide-Binding Switch in Three Dimensions
Top Cited Papers
- 9 November 2001
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5545), 1299-1304
- https://doi.org/10.1126/science.1062023
Abstract
Guanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states. Recent structural studies show that the switch apparatus itself is a conserved fundamental module but that its regulators and effectors are quite diverse in their structures and modes of interaction. Here we will try to define some underlying principles.This publication has 70 references indexed in Scilit:
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