Etiology and management of genitourinary tuberculosis
- 9 December 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Urology
- Vol. 8 (12), 678-688
- https://doi.org/10.1038/nrurol.2011.172
Abstract
Genitourinary tuberculosis (GUTB) is the second most common form of extrapulmonary tuberculosis, with more than 90% of cases occurring in developing countries. Postmortem studies--from before anti-TB therapy was available--have provided insight into the prevalence and natural history of the disease. In GUTB, the kidneys are the most common sites of infection and are infected through hematogenous spread of the bacilli, which then spread through the renal and genital tract. Diagnosis of TB is often delayed owing to the nonspecific nature of its presentation; therefore, a high degree of suspicion should be exercised and a systematic approach should be taken during investigation. Appropriate culture samples should be obtained to tailor treatment. Standard treatment should be administered for 6 months; quadruple therapy for 2 months and dual therapy for 4 months. However, additional drugs and prolonged treatment are required if drug resistance occurs. Although the role of surgery in GUTB has decreased since the advent of anti-TB therapy, it can still have a role as an adjunct to drug treatment. Today, the challenges of GUTB and other forms of TB include increasing rates of drug-resistant cases and co-infection with HIV.Keywords
This publication has 97 references indexed in Scilit:
- Molecular Detection of Mutations Associated with First- and Second-Line Drug Resistance Compared with Conventional Drug Susceptibility Testing of Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 2011
- Rapid Molecular Detection of Extrapulmonary Tuberculosis by the Automated GeneXpert MTB/RIF SystemJournal of Clinical Microbiology, 2011
- Clinical Characteristics of Genitourinary Tuberculosis during a Recent 10-Year Period in One CenterKorean Journal of Urology, 2011
- Rapid Molecular Detection of Tuberculosis and Rifampin ResistanceNew England Journal of Medicine, 2010
- Incidence of Tuberculosis Disease and Latent Tuberculosis Infection in Patients with End Stage Renal Disease in an Endemic RegionRenal Failure, 2010
- Association of Tuberculous Endometritis with Infertility and Other Gynecological Complaints of Women in IndiaJournal of Clinical Microbiology, 2008
- Reconstructive bladder surgery in genitourinary tuberculosisIndian Journal of Urology, 2008
- Surgical management of renal tuberculosisIndian Journal of Urology, 2008
- Postmenopausal Tuberculosis EndometritisInfectious Diseases in Obstetrics and Gynecology, 2007
- Genital tuberculosis—a major pelvic factor causing infertility in Indian womenFertility and Sterility, 1997