Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study
Open Access
- 1 January 2014
- journal article
- research article
- Published by Medknow in Journal of Oral and Maxillofacial Pathology
- Vol. 18 (2), 217-222
- https://doi.org/10.4103/0973-029X.140753
Abstract
Background: Recent studies have indicated that although malignant cells at the invasive tumor front, bare morphological resemblance to the cells at central portion of the tumor, their molecular character differs significantly. E-cadherin is a cell-cell adhesion molecule that connects epithelial cells. This study attempts to correlate the E-cadherin expression at the invasive tumor front with tumor differentiation along with its clinico-pathological parameters. Materials and Methods: Immunohistochemical staining with E-cadherin was carried out on archival cases of primary oral squamous cell carcinomas (n = 30). The E-cadherin expression at the invasive tumor front was analyzed and was linked to clinico-pathological parameters including patient prognosis. Results: The downregulation of E-cadherin expression at the invasive tumor edge when compared with patient's prognosis yielded a significant correlation (P = 0.041) but its correlation with the degree of differentiation determined was not significant (P = 0.27). Also, its association with tumor size and lymph node status was negative. Conclusions: Loss of E-cadherin expression at the invasive tumor front is an important event in the progression of oral squamous cell carcinomas. Tumors with a loss of expression of E-cadherin are those which had a poor prognosisKeywords
This publication has 35 references indexed in Scilit:
- Cancer Stem Cells in Head and Neck Squamous Cell CarcinomaJournal of Oncology, 2011
- Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastasesHead & Neck, 2003
- Deranged expression of the E‐cadherin/β‐catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomasJournal of Oral Pathology & Medicine, 2002
- Expression of bcl-2 and bax in chewing tobacco-induced oral cancers and oral lesions from India.Pathology and Oncology Research, 2002
- Estimating the world cancer burden: Globocan 2000International Journal of Cancer, 2001
- Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavityThe Journal of Pathology, 1998
- Immunohistochemical study of desmosomes in oral squamous cell carcinoma: correlation with cytokeratin and E-cadherin staining, and with tumour behaviourThe Journal of Pathology, 1998
- Mutations of the human E-cadherin (CDH1) geneHuman Mutation, 1998
- Altered expression and function of E‐cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinomaThe Journal of Pathology, 1995
- E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.1991