Pregnancy in 4 women with childhood-onset steroid-sensitive nephrotic syndrome
Open Access
- 3 July 2013
- journal article
- Published by Springer Science and Business Media LLC in CEN Case Reports
- Vol. 3 (1), 63-67
- https://doi.org/10.1007/s13730-013-0087-9
Abstract
Four women with childhood-onset steroid-sensitive nephrotic syndrome (SSNS) had 5 pregnancies. Their age at onset of SSNS was between 4 and 10 years, and age at pregnancy was between 21 and 31 years. Three patients with frequent relapsing nephrotic syndrome (NS) continued to relapse after 20 years of age. Two of them had relapses during 6–32 gestational weeks of pregnancy and were treated with prednisolone (PSL) 10–45 mg/day. One patient delivered a normal baby on 2 pregnancies. Another developed superimposed preeclampsia and her infant showed asymmetrical type of intrauterine growth restriction (IUGR). There was no relapse during pregnancy in 2 patients, including 1 with frequent relapses, who had no relapse over 5 years preceding the pregnancy. In all four patients, normal renal function and complete remission were noted at the last follow-up. Their 5 infants were well at 1–7 years of age. Although hypertension, growth failure of the placenta, and IUGR of the baby may complicate the pregnancy, most pregnancies with SSNS seem to result in normal birth, even when relapses occur during pregnancy and are treated with PSL.Keywords
This publication has 12 references indexed in Scilit:
- Revised Equations for Estimated GFR From Serum Creatinine in JapanAmerican Journal of Kidney Diseases, 2009
- Successful management of membranoproliferative glomerulonephritis type I in pregnancyArchiv für Gynäkologie, 2009
- Final height in children with steroid‐sensitive nephrotic syndromePediatrics International, 2007
- Chronic Kidney Disease and Pregnancy: Maternal and Fetal OutcomesAdvances in Chronic Kidney Disease, 2007
- In utero exposure to immunosuppressive drugs: experimental and clinical studiesPediatric Nephrology, 2002
- Renal biopsy in pregnancies complicated by undetermined renal diseaseActa Obstetricia et Gynecologica Scandinavica, 2001
- Evaluation and Management of Proteinuria and Nephrotic Syndrome in Children: Recommendations From a Pediatric Nephrology Panel Established at the National Kidney Foundation Conference on Proteinuria, Albuminuria, Risk, Assessment, Detection, and Elimination (PARADE)PEDIATRICS, 2000
- Glomerular Disease and PregnancyNephron, 1984
- Pregnancy in patients who have had the idiopathic nephrotic syndrome in childhoodThe Journal of Pediatrics, 1972
- Pregnancy and the Nephrotic SyndromeBMJ, 1969