The global population of SARS-CoV-2 is composed of six major subtypes
Open Access
- 26 October 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 10 (1), 1-9
- https://doi.org/10.1038/s41598-020-74050-8
Abstract
The World Health Organization characterized COVID-19 as a pandemic in March 2020, the second pandemic of the twenty-first century. Expanding virus populations, such as that of SARS-CoV-2, accumulate a number of narrowly shared polymorphisms, imposing a confounding effect on traditional clustering methods. In this context, approaches that reduce the complexity of the sequence space occupied by the SARS-CoV-2 population are necessary for robust clustering. Here, we propose subdividing the global SARS-CoV-2 population into six well-defined subtypes and 10 poorly represented genotypes named tentative subtypes by focusing on the widely shared polymorphisms in nonstructural (nsp3, nsp4, nsp6, nsp12, nsp13 and nsp14) cistrons and structural (spike and nucleocapsid) and accessory (ORF8) genes. The six subtypes and the additional genotypes showed amino acid replacements that might have phenotypic implications. Notably, three mutations (one of them in the Spike protein) were responsible for the geographical segregation of subtypes. We hypothesize that the virus subtypes detected in this study are records of the early stages of SARS-CoV-2 diversification that were randomly sampled to compose the virus populations around the world. The genetic structure determined for the SARS-CoV-2 population provides substantial guidelines for maximizing the effectiveness of trials for testing candidate vaccines or drugs.Keywords
Funding Information
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
This publication has 60 references indexed in Scilit:
- Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane VesiclesmBio, 2013
- Viral Quasispecies EvolutionMicrobiology and Molecular Biology Reviews, 2012
- A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus EntryJournal of Virology, 2011
- Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2Journal of Virology, 2010
- The Coronavirus Nucleocapsid Protein Is Dynamically Associated with the Replication-Transcription ComplexesJournal of Virology, 2010
- Nidovirales: Evolving the largest RNA virus genomeVirus Research, 2006
- Molecular evolution and multilocus sequence typing of 145 strains of SARS‐CoVFEBS Letters, 2005
- Phylogeny of SARS-CoV as inferred from complete genome comparisonChinese Science Bulletin, 2003
- Phylogeny of SARS-CoV as inferred from complete genome comparisonChinese Science Bulletin, 2003
- PHYLOGEOGRAPHIC HISTORY OF THE LAND SNAIL CANDIDULA UNIFASCIATA (HELICELLINAE, STYLOMMATOPHORA): FRAGMENTATION, CORRIDOR MIGRATION, AND SECONDARY CONTACTEvolution, 2002