Cell exfoliation in the human colon: Myth, reality and implications for colorectal cancer screening
- 1 June 2007
- journal article
- review article
- Published by Wiley in International Journal of Cancer
- Vol. 120 (11), 2281-2289
- https://doi.org/10.1002/ijc.22647
Abstract
Colonocyte exfoliation in the human colon constitutes a unique mechanism of cell population control that can undergo significant changes under different physiological and pathological conditions. Being closely related to the apoptosis and anoikis, cell exfoliation from colonic epithelium appears to be a relatively rare event in normal conditions, but its rate dramatically increases in neoplasia, when cell removal by apoptosis in situ does not function properly. Several studies show that significant numbers of exfoliated colonocytes are not lost in the faecal contents of the gut, but retained in the mucocellular layer overlying colonic mucosa. Recent observations allow hypothesizing that the mucocellular layer containing exfoliated colonocytes may gradually migrate distally, eventually leading to the accumulation of the cells exfoliated from malignant colorectal tumours on the surface of the rectal mucosa. Implications of exfoliated colonocyte analysis to colorectal cancer screening and early diagnosis are discussed.This publication has 63 references indexed in Scilit:
- Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fissionProceedings of the National Academy of Sciences of the United States of America, 2006
- Self-Renewal and Cancer of the Gut: Two Sides of a CoinScience, 2005
- Cancer genes and the pathways they controlNature Medicine, 2004
- STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENTGut, 2004
- Migrating colonic crypt epithelial cells: primary targets for transformationCarcinogenesis: Integrative Cancer Research, 2002
- Emerging concepts in colorectal neoplasiaGastroenterology, 2002
- Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fissionGut, 2002
- Top-down morphogenesis of colorectal tumorsProceedings of the National Academy of Sciences of the United States of America, 2001
- Stem cells: the intestinal stem cell as a paradigmCarcinogenesis: Integrative Cancer Research, 2000
- A genetic model for colorectal tumorigenesisCell, 1990