Direct activation of the ion channel TRPA1 by Ca2+
Top Cited Papers
- 28 January 2007
- journal article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 10 (3), 277-279
- https://doi.org/10.1038/nn1843
Abstract
TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.Keywords
This publication has 15 references indexed in Scilit:
- Gating of TRP channels: a voltage connection?The Journal of Physiology, 2005
- Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channelsPflügers Archiv - European Journal of Physiology, 2005
- Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and HearingJournal of Neuroscience, 2005
- Regulation of the Ca2+ Sensitivity of the Nonselective Cation Channel TRPM4Published by Elsevier BV ,2005
- Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1Nature, 2004
- TRP channels as cellular sensorsNature, 2003
- Voltage Dependence of the Ca2+-activated Cation Channel TRPM4Published by Elsevier BV ,2003
- TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation ChannelCurrent Biology, 2003
- ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold TemperaturesCell, 2003
- Structures of EF-hand Ca 2+-binding proteins: Diversity in the organization, packing and response to Ca 2+ BindingBioMetals, 1998