Peripheral nerve regeneration is delayed in neuropilin 2–deficient mice
- 9 July 2008
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 86 (14), 3163-3169
- https://doi.org/10.1002/jnr.21766
Abstract
Peripheral nerve transection or crush induces expression of class 3 semaphorins by epineurial and perineurial cells at the injury site and of the neuropilins neuropilin‐1 and neuropilin‐2 by Schwann and perineurial cells in the nerve segment distal to the injury. Neuropilin‐dependent class 3 semaphorin signaling guides axons during neural development, but the significance of this signaling system for regeneration of adult peripheral nerves is not known. To test the hypothesis that neuropilin‐2 facilitates peripheral‐nerve axonal regeneration, we crushed sciatic nerves of adult neuropilin‐2‐deficient and littermate control mice. Axonal regeneration through the crush site and into the distal nerve segment, repression by the regenerating axons of Schwann cell p75 neurotrophin receptor expression, remyelination of the regenerating axons, and recovery of normal gait were all significantly slower in the neuropilin‐2‐deficient mice than in the control mice. Thus, neuropilin‐2 facilitates peripheral‐nerve axonal regeneration.Keywords
This publication has 56 references indexed in Scilit:
- Human Neuroma Contains Increased Levels of Semaphorin 3A, Which Surrounds Nerve Fibers and Reduces Neurite ExtensionIn VitroJournal of Neuroscience, 2007
- Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3FDevelopment, 2007
- Lens-derived Semaphorin3A regulates sensory innervation of the corneaDevelopmental Biology, 2007
- Targeting Sensory Axon Regeneration in Adult Spinal CordJournal of Neuroscience, 2007
- Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensationJournal of Neurobiology, 2007
- Schwann cell-autonomous role of neuropilin-2Journal of Neuroscience Research, 2005
- Differential Requirements for Semaphorin 3F and Slit-1 in Axonal Targeting, Fasciculation, and Segregation of Olfactory Sensory Neuron ProjectionsJournal of Neuroscience, 2004
- Injury-Induced Class 3 Semaphorin Expression in the Rat Spinal CordExperimental Neurology, 2002
- Expression of nerve growth factor receptor in human peripheral neuropathiesAnnals of Neurology, 1988
- Tight junction contact events and temporary gap junctions in the sciatic nerve fibres of the chicken during Wallerian degeneration and subsequent regenerationJournal of Neurocytology, 1982